According to a report published by Daily Nation on November 12, 2026, the match carries special significance for McCarthy, who remains South Africa's all-time leading goalscorer.
The former Bafana Bafana striker will return to familiar territory at Orlando Stadium in Soweto, but this time his responsibility will be guiding Kenya against the country where he built his football legacy.
McCarthy scored 31 goals in 81 appearances for South Africa before retiring from international football in 2013. His experience also includes winning the UEFA Champions League with Portuguese giants Porto.
However, the Kenyan coach now has a different assignment as he attempts to help Harambee Stars secure their first-ever victory over Bafana Bafana.
South Africa enter the encounter with confidence after winning their opening two Group D matches against Guinea and Eritrea. Their performances have established them as serious contenders in the qualifying campaign.
Kenya, meanwhile, have an opportunity to measure their progress against one of Africa's established football sides.
The encounter will also bring together two respected South African coaches, with Pitso Mosimane leading Bafana Bafana against his former country's football legend.
Beyond the contest on the pitch, McCarthy is also dealing with reported salary arrears involving members of his technical bench.
The coach recently indicated that he could seek intervention from FIFA and the Confederation of African Football if the outstanding payments remain unresolved.
However, he has maintained that the dispute will not distract him from his responsibility to improve Kenyan football.
The two teams are also scheduled to meet again in Nairobi on November 17, giving Kenya another opportunity to test themselves against South Africa.
Kenya, Uganda and Tanzania have already secured automatic places at the 2027 AFCON finals as co-hosts. Nevertheless, the qualifiers provide valuable competitive preparation ahead of the continental tournament.
For Kenyan supporters, Friday's encounter presents an important opportunity to assess how far McCarthy has taken the national team.
Can Harambee Stars finally overcome Bafana Bafana under their South African coach, or will McCarthy's homecoming end in disappointment?